Enhanced Permeation of Antiemetic Drug from Buccoadhesive Tablets by Using Bile Salts as Permeation Enhancers: Formulation characterization, In Vitro and Ex Vivo Studies
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چکیده
منابع مشابه
Enhanced Permeation of an Antiemetic Drug from Buccoadhesive Tablets by Using Bile Salts as Permeation Enhancers: Formulation Characterization, In Vitro, and Ex Vivo Studies
Buccal bioadhesive bilayer tablets of prochlorperazine maleate were designed and formulated by using buccoadhesive polymers such as hydroxypropylmethyl cellulose, Carbopol 934P, and sodium alginate. Physicochemical characteristics like the uniformity of weight, hardness, thickness, surface pH, drug content, swelling index, microenvironment pH, in vitro drug release, and in vivo buccoadhesion ti...
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The objective of the paper is to study the effect of a permeation enhancer, sodium taurocholate on permeation of Ondansetron HCl from bioadhesive buccal tablet formulation by performing ex-vivo permeation experiments using porcine buccal mucosa. Optimized formulation has selected based on in-vitro drug release studies of bilayered bioadhesive buccal tablets. To the optimized formulation, 10mM s...
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ژورنال
عنوان ژورنال: Scientia Pharmaceutica
سال: 2016
ISSN: 0036-8709,2218-0532
DOI: 10.3797/scipharm.1505-15